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N-Acetyllactosamine 6-Sulfate Sodium Salt CAS 145447-78-5

FC-151

LacNAc(1S); 2-(Acetylamino)-2-deoxy-4-O-β-D-galactopyranosyl-D-glucose 6-(Hydrogen Sulfate) Monosodium Salt; Galβ-(1-4)-GlcNAc(6S)

LacNAc(1S), ≥ 90.0% purity.

Used in the screening and diagnosis of Morquio A syndrome (MPS IVA). Validation of an LC-MS/MS assay for detecting relevant disaccharides from keratan sulfate as a biomarker for Morquio A syndrome.1,2

N-Acetyllactosamine derivatives were tested as acceptors for α1,3-L-Fucosyltransferase present in human ovarian cancer sera and ovarian tumor.3-7

1. L.A. Martell et. al. Bioanalysis, 3(16), 1855-1866 (2011)
2. C. Auray-Blais et. al. Bioanalysis, 8(3), 179-191 (2016)
3. Lasky, L. et al. Science, 258, 964 (1992)
4. Hemmerich, S. et al. Biochemistry, 33, 4830 (1994)
5. Clarke, J. et al. J. Biol. Chem., 271, 10317 (1996)
6. Komba, S. et al. Bioorg. Med. Chem., 4, 1833 (1996)
7. Yoshino, K. et al. J. Med. Chem., 40, 455 (1997)

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