α-Galactosyl Ceramide CAS 158021-47-7


KRN7000, alpha-galactosyl ceramide, α-GalCer, alpha-GalCer, aGC

α-Galactosylceramide was originally isolated from an extract of the Okinawan marine sponge Agelas mauritianus. α-Galactosylceramide is a specific ligand for human and mouse natural killer T (NKT) cells and exhibits potent anti-tumor activity with murine in vivo experiments including subcutaneous implanted model and metastatic models in the liver and lung. In the liver metastatic models, treatment with α-galactosylceramide suppressed the growth of tumors and prolonged the survival term of the tumor-bearing mice. α-Galactosylceramide has been reported to show various immunological effects in infectious diseases, autoimmune disease and graft versus host disease in mice.1

Chemically synthesized. Provided with a BSE/TSE statement.

Purity by HPLC-CAD – example chromatogram on the right.

Larger quantities available for shipment. GMP material availableplease enquire

1. Carreño, L. J.; Saavedra-Ãvila, N. A.; Porcelli, S. A. Clin. & Trans. Imm. 5, e69 (2016)

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