Kifunensine CAS 109944-15-2


An alkaloid produced by Kitasatosporia kifunense, kifunensine is a potent inhibitor of the mannosidase I enzyme (50 to 100 times more potent than deoxymannojirimycin). While ineffective against mannosidase II or the endoplasmic reticulum alpha-mannosidase, it has also been shown to weakly inhibit arylmannosidase.1,2

Provided with a BSE/TSE statement.

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1. Iwami, M.; Nakayama, O.; Terano, H. J. Antibiotics 1987, 40, 612-622.

2. Elbein, A. D.; Tropea, J. E.; Mitchell, M.; Kaushal, G. P. J. Biol. Chem. 1990, 265, 15599-15605.

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