Keratanase II (truncated sequence from Bacillus circulans expressed in E. coli)



Used in the screening and diagnosis of Morquio A syndrome (MPS IVA). Validation of an LC-MS/MS assay for detecting relevant disaccharides from keratan sulfate as a biomarker for Morquio A syndrome.1-3

To reconstitute: Tap vial gently on bench. Remove crimp cap and stopper. Add 120μl sterile MilliQ water (or equivalent) and swirl gently until clear solution obtained. Reconstituted protein can be stored at 4°C or in small aliquots at -20°C or below. Avoid repeated freeze-thaw cycles.

1. L.A. Martell et al. Bioanalysis, 3(16), 1855-1866 (2011).
2. M. Steward et al. Clinical Biochemistry, 48, 796-802 (2015).
3. C. Auray-Blais et. al. Bioanalysis, 8(3), 179-191 (2016).

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